Curated Information
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Curated Information Page
PubMed Id: 12027890 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hörtner M, et al. (2002) A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur J Biochem 269, 2516-26 12027890
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y368-p - EpoR (human) ▲
Orthologous residues
EpoR (human): Y368‑p, EpoR (mouse): Y367‑p, EpoR (rat): Y367‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SOCS3 (human) SH2 Induces electrophoretic visualization, co-immunoprecipitation

Y426-p - EpoR (human) ▲
Orthologous residues
EpoR (human): Y426‑p, EpoR (mouse): Y425‑p, EpoR (rat): Y425‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SOCS3 (human) SH2 Induces electrophoretic visualization, co-immunoprecipitation

Y454-p - EpoR (human) ▲
Orthologous residues
EpoR (human): Y454‑p, EpoR (mouse): Y453‑p, EpoR (rat): Y453‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SOCS3 (human) SH2 Induces electrophoretic visualization, co-immunoprecipitation

Y456-p - EpoR (human) ▲
Orthologous residues
EpoR (human): Y456‑p, EpoR (mouse): Y455‑p, EpoR (rat): Y455‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SOCS3 (human) SH2 Induces electrophoretic visualization, co-immunoprecipitation


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