Curated Information
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PubMed Id: 11071637 
Duarte RF, Frank DA (2000) SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood 96, 3422-30 11071637
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S727-p - STAT3 (human)
Orthologous residues
STAT3 (human): S727‑p, STAT3 iso2 (human): S726‑p, STAT3 (mouse): S727‑p, STAT3 iso2 (mouse): , STAT3 iso3 (mouse): S726‑p, STAT3 (rat): S727‑p, STAT3 (cow): S727‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  leukemia
 Relevant cell lines - cell types - tissues:  Mo7e (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
G-CSF increase
wortmannin G-CSF inhibit treatment-induced increase modest inhibition
SCF increase
wortmannin SCF inhibit treatment-induced decrease modest inhibition
G-CSF SCF augment treatment-induced increase
wortmannin G-CSF, SCF no effect upon treatment-induced increase
PD98059 SCF inhibit treatment-induced increase modest inhibition
PD98059 G-CSF inhibit treatment-induced increase modest inhibition
PD98059 G-CSF, SCF no effect upon treatment-induced increase
PD98059, wortmannin SCF inhibit treatment-induced increase
PD98059, wortmannin G-CSF inhibit treatment-induced increase
PD98059, wortmannin G-CSF inhibit treatment-induced increase
H-7 SCF no effect upon treatment-induced increase
H-7 G-CSF inhibit treatment-induced increase
H-7 G-CSF no effect upon treatment-induced increase


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