Curated Information
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Curated Information Page
PubMed Id: 10660304 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Yokogami K, Wakisaka S, Avruch J, Reeves SA (2000) Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol 10, 47-50 10660304
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y705-p - STAT3 (human) ▲
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 iso3 (human): Y705‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), NBFL
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CNTF (human) increase
rapamycin CNTF (human) no effect upon treatment-induced increase
PD98059 CNTF (human) no change compared to control
H-7 CNTF (human) no effect upon treatment-induced increase

S727-p - STAT3 (human) ▲
Orthologous residues
STAT3 (human): S727‑p, STAT3 iso2 (human): S726‑p, STAT3 iso3 (human): ‑, STAT3 (mouse): S727‑p, STAT3 iso2 (mouse): ‑, STAT3 iso3 (mouse): S726‑p, STAT3 (rat): S727‑p, STAT3 (cow): S727‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), NBFL
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE mTOR (mouse)
 Comments:  STAT3 peptide
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CNTF (human) increase
rapamycin CNTF (human) inhibit treatment-induced increase
H-7 CNTF (human) no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  transcription, altered
 Comments:  induced by CNTF


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