Curated Information
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Curated Information Page
PubMed Id: 12444928 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wollberg P, et al. (2003) The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J 370, 1033-8 12444928
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y568-p - Kit (human) ▲
Orthologous residues
Kit (human): Y568‑p, Kit (mouse): Y571‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
APS (human) Induces sequence-specific competitor, pull-down assay, co-immunoprecipitation
Src (human) SH2 Induces pull-down assay
SHP-2 (human) SH2 Induces pull-down assay

Y936-p - Kit (human) ▲
Orthologous residues
Kit (human): Y936‑p, Kit (mouse): Y938‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (human) SH2 Induces pull-down assay
Grb7 (human) SH2 Induces pull-down assay
APS (human) Induces sequence-specific competitor, pull-down assay, co-immunoprecipitation


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