Curated Information

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Curated Information Page

PubMed Id: 12032545

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Legg JW, et al. (2002) A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nat Cell Biol 4, 399-407 12032545

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S672-p - CD44 (human)

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Orthologous residues

CD44 (human): S672‑p, CD44 (mouse): S708‑p, CD44 iso2 (mouse): S293‑p, CD44 (rat): S433‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], RPM-MC (melanocyte)

Cellular systems studied: cell lines

Species studied: human, mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKCA (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
phorbol ester				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Effect of modification (process): cytoskeletal reorganization

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
ezrin (human)		Induces			microscopy-colocalization, FRET

S706-p - CD44 (human)

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