Curated Information
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Curated Information Page
PubMed Id: 12052877 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Oliver CJ, et al. (2002) Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Mol Cell Biol 22, 4690-701 12052877
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S461-p - neurabin 1 (rat)
Orthologous residues
neurabin 1 (human): S460‑p, neurabin 1 iso2 (human): , neurabin 1 (mouse): S461‑p, neurabin 1 (rat): S461‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP1CA (rat) pharmacological inhibitor of upstream enzyme
KINASE PKACA (rat) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid increase
cAMP analog increase
8-Rp-cAMP decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
p70S6K (rat) Induces enzymatic activity, induced co-immunoprecipitation, electrophoretic visualization
PPP1CA (rat) Induces enzymatic activity, induced co-immunoprecipitation, electrophoretic visualization


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