Curated Information
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Curated Information Page
PubMed Id: 14517306 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Miravet S, et al. (2003) Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Mol Cell Biol 23, 7391-402 14517306
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y654-p - CTNNB1 (human) ▲
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE HER2 (human)
KINASE EGFR (human)

Y133-p - desmoplakin 3 (human) ▲
Orthologous residues
desmoplakin 3 (human): Y133‑p, desmoplakin 3 (mouse): Y133‑p, desmoplakin 3 (rat): Y133‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  IEC-18 (epithelial), MDCK (epithelial), RWP1 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNA1 (human) Disrupts pull-down assay
desmoplakin (human) Induces pull-down assay
TCF4 (human) Disrupts pull-down assay

Y550-p - desmoplakin 3 (human) ▲
Orthologous residues
desmoplakin 3 (human): Y550‑p, desmoplakin 3 (mouse): Y550‑p, desmoplakin 3 (rat): Y550‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  IEC-18 (epithelial), MDCK (epithelial), RWP1 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Fer (human)
KINASE Fyn (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KRas (human) increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
desmoplakin (human) Disrupts pull-down assay
CTNNA1 (human) Induces pull-down assay

Y644-p - desmoplakin 3 (human) ▲
Orthologous residues
desmoplakin 3 (human): Y644‑p, desmoplakin 3 (mouse): Y644‑p, desmoplakin 3 (rat): Y644‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  IEC-18 (epithelial), MDCK (epithelial), RWP1 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  dog, human, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KRas (human) increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CDH1 (human) Disrupts pull-down assay
desmoplakin (human) Induces pull-down assay
CTNNA1 (human) Disrupts pull-down assay


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