Curated Information
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Curated Information Page
PubMed Id: 12122038 
Chetkovich DM, et al. (2002) Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. J Neurosci 22, 5791-6 12122038
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T321-p - Stargazin (rat)
Orthologous residues
Stargazin (human): T321‑p, Stargazin (mouse): T321‑p, Stargazin (rat): T321‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (rat) transfection of constitutively active enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PSD-95 (rat) Disrupts co-immunoprecipitation, electrophoretic visualization


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