Curated Information

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Curated Information Page

PubMed Id: 15078887

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Nair VD, Yuen T, Olanow CW, Sealfon SC (2004) Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress. J Biol Chem 279, 27494-501 15078887

S15-p - p53 (human)

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Orthologous residues

p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: adrenal cancer, pheochromocytoma

Relevant cell lines - cell types - tissues: PC-12 (chromaffin), SN4741 (neuron)

Cellular systems studied: cell lines

Species studied: human, rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
H2O2				increase
PD98059	H2O2			no effect upon treatment-induced increase

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