Curated Information
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Curated Information Page
PubMed Id: 12665528 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Inomata H, et al. (2003) A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278, 22946-55 12665528
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T743-p - APP (rat)
Orthologous residues
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  human, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JNK1 (human) inhibition of upstream enzyme, activation of upstream enzyme
KINASE JNK1 (human) inhibition of upstream enzyme, pharmacological activator of upstream enzyme, genetic transfer of wild-type enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
UV increase
sorbitol increase


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