Curated Information

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Curated Information Page

PubMed Id: 15611664

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Tsvetkov L, Stern DF (2005) Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage. Cell Cycle 4, 166-71 15611664

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S137-p - PLK1 (human)

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Orthologous residues

PLK1 (human): S137‑p, PLK1 (mouse): S137‑p, PLK1 (rat): S137‑p, PLK1 (frog): S128‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 293T (epithelial) [PLK1 (human)], HeLa (cervical) [PLK1 (human)]

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
nocodazole				increase
adriamycin	nocodazole			inhibit treatment-induced increase

T210-p - PLK1 (human)

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