Curated Information
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Curated Information Page
PubMed Id: 15710330 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Mohi MG, et al. (2005) Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell 7, 179-91 15710330
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y546-p - SHP-2 (human)
Orthologous residues
SHP‑2 (human): Y546‑p, SHP‑2 iso2 (human): Y542‑p, SHP‑2 (mouse): Y546‑p, SHP‑2 (rat): Y546‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  bone marrow
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Comments:  Y542 mutation (E76K/Y542F) markedly impaired transformation, Y580 mutation (E76K/Y580F) had little effect

Y584-p - SHP-2 (human)
Orthologous residues
SHP‑2 (human): Y584‑p, SHP‑2 iso2 (human): Y580‑p, SHP‑2 (mouse): Y584‑p, SHP‑2 (rat): Y584‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  bone marrow
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Comments:  Y542 mutation (E76K/Y542F) markedly impaired transformation, Y580 mutation (E76K/Y580F) had little effect


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