Curated Information
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Curated Information Page
PubMed Id: 15681610 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Dai J, Sultan S, Taylor SS, Higgins JM (2005) The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev 19, 472-88 15681610
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T4-p - H3 (human)
Orthologous residues
H3 (human): T4‑p, H3 (mouse): T4‑p, H3 iso2 (mouse): T4‑p, H3 iso3 (mouse): T4‑p, H3 (rat): T4‑p, H3 iso3 (rat): T4‑p, H3 (pig): T4‑p, H3 (chicken): T4‑p, H3 (cow): T4‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical), U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Haspin (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Haspin (human) antisense inhibition of upstream enzyme, transfection of inactive enzyme, transfection of wild-type enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ZM447439 no change compared to control

S11-p - H3 (human)
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical), U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ZM447439 decrease

S29-p - H3 (human)
Orthologous residues
H3 (human): S29‑p, H3 (mouse): S29‑p, H3 iso2 (mouse): S29‑p, H3 iso3 (mouse): S29‑p, H3 (rat): S29‑p, H3 iso3 (rat): S29‑p, H3 (pig): S29‑p, H3 (chicken): S29‑p, H3 (cow): S29‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical), U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human


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