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Orthologous residues
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p53 (human): K386‑u, p53 (mouse): K380‑u, p53 iso2 (mouse): ‑, p53 (rat): K384‑u, p53 (rabbit): K384‑u, p53 (monkey): K386‑u
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, western blotting
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Disease tissue studied:
bone cancer
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Relevant cell lines - cell types - tissues:
Saos-2 (bone cell)
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Cellular systems studied:
cell lines
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Species studied:
human
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Comments:
SUMO-1 modification
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Enzymes shown to modify site in vitro:
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Downstream Regulation
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Effect of modification (process):
transcription, altered
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Comments:
stimulates the transcriptional activity of p53
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