Curated Information
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Curated Information Page
PubMed Id: 10562557 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rodriguez MS, et al. (1999) SUMO-1 modification activates the transcriptional response of p53. EMBO J 18, 6455-61 10562557
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K386-ub - p53 (human)
Orthologous residues
p53 (human): K386‑ub, p53 (mouse): K380‑ub, p53 iso2 (mouse): , p53 (rat): K384‑ub, p53 (rabbit): K384‑ub, p53 (monkey): K386‑ub
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  Saos-2 (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  SUMO-1 modification
 Enzymes shown to modify site in vitro
Type Enzyme
SUMO LIGASE UBC9 (human)
Downstream Regulation
 Effect of modification (process):  transcription, induced
 Comments:  stimulates the transcriptional activity of p53


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