Curated Information

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Curated Information Page

PubMed Id: 11861384

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Shono T, et al. (2002) Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer Res 62, 1069-76 11861384

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S15-p - p53 (human)

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Orthologous residues

p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p

Characterization

Methods used to characterize site in vivo: phosphoamino acid analysis, western blotting

Disease tissue studied: brain cancer, glioblastoma, glioblastoma multiforme, glioma

Relevant cell lines - cell types - tissues: U251 (glial), U373 MG (glial), U87MG (glial)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Manipulated Protein	Effect	Notes
	p53 (human)	increase	exogenous p53 expressed in mutant p53 cells
ionizing radiation	p53 (human)	increase
cisplatin	p53 (human)	increase	exogenous p53 expressed in WT p53 cells

Downstream Regulation

Effect of modification (process): apoptosis, induced

S20-p - p53 (human)

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