Curated Information
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Curated Information Page
PubMed Id: 9233789 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804 9233789
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S29-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S29‑p, CTNNB1 (mouse): S29‑p, CTNNB1 (rat): S29‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (mouse) modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LLnL increase
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination

S33-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (mouse) modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LLnL increase
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination

S37-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (mouse) modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LLnL increase
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination

T41-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (mouse) modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LLnL increase
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination

S45-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): S45‑p, CTNNB1 (mouse): S45‑p, CTNNB1 (rat): S45‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (mouse) modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LLnL increase
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination


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