Curated Information
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Curated Information Page
PubMed Id: 15033922 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ho L, et al. (2004) Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 18, 902-4 15033922
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S9-p - GSK3B (human)
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  Tg2576 mice
Downstream Regulation
 Effect of modification (function):  protein degradation
Associated Diseases
Diseases: Alterations: Comments:
type 2 diabetes decreased
Alzheimer's disease decreased

S473-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  Tg2576 mice
Associated Diseases
Diseases: Alterations: Comments:
type 2 diabetes decreased

S21-p - GSK3A (mouse)
Orthologous residues
GSK3A (human): S21‑p, GSK3A (mouse): S21‑p, GSK3A (rat): S21‑p, GSK3A (cow): S21‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  Tg2576 mice
Downstream Regulation
 Effect of modification (function):  protein degradation
Associated Diseases
Diseases: Alterations: Comments:
type 2 diabetes decreased
Alzheimer's disease decreased

Y1179-p - InsR (mouse)
Orthologous residues
InsR (human): Y1189‑p, InsR iso2 (human): Y1177‑p, InsR (mouse): Y1179‑p, InsR (rat): Y1190‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  Tg2576 mice
Associated Diseases
Diseases: Alterations: Comments:
type 2 diabetes decreased

Y1180-p - InsR (mouse)
Orthologous residues
InsR (human): Y1190‑p, InsR iso2 (human): Y1178‑p, InsR (mouse): Y1180‑p, InsR (rat): Y1191‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
 Comments:  Tg2576 mice
Associated Diseases
Diseases: Alterations: Comments:
type 2 diabetes decreased


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