Curated Information
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Curated Information Page
PubMed Id: 12198493 
Vadlamudi RK, et al. (2002) Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4, 681-90 12198493
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S2152-p - FLNA (human)
Orthologous residues
FLNA (human): S2152‑p, FLNA iso2 (human): S2144‑p, FLNA (mouse): S2152‑p, FLNA (rat): S2144‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Disease tissue studied:  breast cancer, melanoma skin cancer
 Relevant cell lines - cell types - tissues:  A7 (melanocyte), M2 (melanocyte), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PAK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PAK1 (human) transfection of constitutively active enzyme, co-immunoprecipitation, microscopy-colocalization, pharmacological activator of upstream enzyme, inhibition of upstream enzyme, transfection of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heregulin increase
peptide inhibitor heregulin inhibit treatment-induced increase PAK1 auto-inhibitory domain
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization

S2292-p - FLNA (human)
Orthologous residues
FLNA (human): S2292‑p, FLNA iso2 (human): S2284‑p, FLNA (mouse): S2292‑p, FLNA (rat): S2284‑p
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PAK1 (human)

S2370-p - FLNA (human)
Orthologous residues
FLNA (human): S2370‑p, FLNA iso2 (human): S2362‑p, FLNA (mouse): S2370‑p, FLNA (rat): S2362‑p
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PAK1 (human)

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