Curated Information
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Curated Information Page
PubMed Id: 10844017 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Snyder GL, et al. (2000) Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo. J Neurosci 20, 4480-8 10844017
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T34-p - DARPP-32 (mouse) ▲
Orthologous residues
DARPP‑32 (human): T34‑p, DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, neostriatum'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cyclosporin A no change compared to control
cocaine increase
methamphetamine increase

S849-p - GluR1 (mouse) ▲
Orthologous residues
GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, neostriatum'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
dopamine no change compared to control
SKF81297 no change compared to control
quinpirole no change compared to control
calyculin A increase
okadaic acid no change compared to control
cyclosporin A no change compared to control
cocaine no change compared to control
methamphetamine no change compared to control

S863-p - GluR1 (mouse) ▲
Orthologous residues
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, neostriatum'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
dopamine increase
SCH 23390 dopamine inhibit treatment-induced increase
sulpiride dopamine no effect upon treatment-induced increase
dopamine DARPP-32 (mouse) inhibit treatment-induced increase null
SKF81297 increase
quinpirole no change compared to control
calyculin A increase
okadaic acid increase
cyclosporin A no change compared to control
cocaine increase
cocaine DARPP-32 (mouse) inhibit treatment-induced increase null
methamphetamine increase
methamphetamine DARPP-32 (mouse) inhibit treatment-induced increase null


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