Curated Information
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Curated Information Page
PubMed Id: 12231622 
Chan DW, et al. (2002) Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 16, 2333-8 12231622
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T2609-p - DNAPK (human)
Orthologous residues
DNAPK (human): T2609‑p, DNAPK (mouse): T2605‑p, DNAPK (rat): T2603‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE DNAPK (human)
 Comments:  autophosphorylation
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
wortmannin ionizing radiation inhibit treatment-induced increase
ionizing radiation ATM (human) increase
siRNA ionizing radiation Ku70 (human) inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  T2609 phosphorylation is required for double-strand break repair.


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