Curated Information
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Curated Information Page
PubMed Id: 14724572 
Lamalice L, Houle F, Jourdan G, Huot J (2004) Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 23, 434-45 14724572
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1214-p - VEGFR2 (human)
Orthologous residues
VEGFR2 (human): Y1214‑p, VEGFR2 (mouse): Y1212‑p, VEGFR2 (rat): Y1210‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], HUVEC (endothelial), PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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