Curated Information
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Curated Information Page
PubMed Id: 14707117 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Badour K, et al. (2004) Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J Exp Med 199, 99-112 14707117
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Y293-p - WASP (mouse)
Orthologous residues
WASP (human): Y291‑p, WASP (mouse): Y293‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), T lymphocyte-blood
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTP-PEST (mouse) transfection of wild-type enzyme, transfection of inactive enzyme
KINASE Fyn (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme, transfection of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD28 increase
anti-CD3 increase
Downstream Regulation
 Effect of modification (function):  activity, induced
 Effect of modification (process):  cytoskeletal reorganization


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