Curated Information
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Curated Information Page
PubMed Id: 9012831 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yang W, Desiderio S (1997) BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc Natl Acad Sci U S A 94, 604-9 9012831
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y223-p - Btk (mouse)
Orthologous residues
Btk (human): Y223‑p, Btk (mouse): Y223‑p, Btk (rat): Y224‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial) [Btk (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  fragments of BTK (aa 219-268 and aa 169-382) carrying mutation Y223F were overexpressed
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GTF2I (human) Induces enzymatic activity, induced co-immunoprecipitation

Y551-p - Btk (mouse)
Orthologous residues
Btk (human): Y551‑p, Btk (mouse): Y551‑p, Btk (rat): Y552‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial) [Btk (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  fragments of BTK (aa 219-268 and aa 169-382) carrying mutation Y551F were overexpressed
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GTF2I (human) Not reported co-immunoprecipitation


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