Curated Information
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Curated Information Page
PubMed Id: 11311121 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Woods YL, et al. (2001) The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochem J 355, 609-15 11311121
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T212-p - Tau iso8 (human)
Orthologous residues
Tau (human): T529‑p, Tau iso2 (human): T154‑p, Tau iso3 (human): T118‑p, Tau iso5 (human): T212‑p, Tau iso6 (human): T154‑p, Tau iso7 (human): T183‑p, Tau iso8 (human): T212‑p, Tau (mouse): T504‑p, Tau iso3 (mouse): T201‑p, Tau iso7 (mouse): T161‑p, Tau (rat): T523‑p, Tau (cow): T219‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE DYRK1A (human)
KINASE DYRK2 (human)
 Comments:  phosphorylation of this site by DYRK2 or DYRK1A facilitates phosphorylation of T208 by GSK3 (in vitro experiments)

S535-p - eIF2B-epsilon (rat)
Orthologous residues
eIF2B‑epsilon (human): S540‑p, eIF2B‑epsilon (mouse): S536‑p, eIF2B‑epsilon (rat): S535‑p, eIF2B‑epsilon (rabbit): S540‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
 Comments:  phosphorylation of this site is facilitated by earlier phosphorylation of S539

S539-p - eIF2B-epsilon (rat)
Orthologous residues
eIF2B‑epsilon (human): S544‑p, eIF2B‑epsilon (mouse): S540‑p, eIF2B‑epsilon (rat): S539‑p, eIF2B‑epsilon (rabbit): S544‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
KINASE DYRK1A (human)
KINASE DYRK2 (human)
 Comments:  phosphorylation of this site by ERK2, DYRK1A or DYRK2 facilitates phosphorylation of S535 by ERK2 (data in vitro)


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