Curated Information
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Curated Information Page
PubMed Id: 15048125 
Yeh E, et al. (2004) A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 6, 308-18 15048125
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T58-p - Myc (mouse)
Orthologous residues
Myc (human): T58‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293A (epithelial), BJ (fibroblast) [NBS1 (human)], MEF (fibroblast) [IGF1R (mouse)], REF52 (fibroblast)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, mouse, rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Pin1 (human) Induces protein degradation co-immunoprecipitation

S62-p - Myc (mouse)
Orthologous residues
Myc (human): S62‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293A (epithelial), BJ (fibroblast) [NBS1 (human)], MEF (fibroblast) [IGF1R (mouse)], REF52 (fibroblast)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, mouse, rat
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PPP2CA (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid increase
serum increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, phosphorylation, protein stabilization
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Pin1 (mouse) Induces


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