Curated Information
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Curated Information Page
PubMed Id: 10413505 
Hammes SR, Shapiro MJ, Coughlin SR (1999) Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry 38, 9308-16 10413505
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S391-p - PAR1 (human)
Orthologous residues
PAR1 (human): S391‑p, PAR1 (mouse): S396‑p, PAR1 (rat): S398‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), oocyte, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  frog, monkey, rat
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  receptor shutoff (not internalization)

S392-p - PAR1 (human)
Orthologous residues
PAR1 (human): S392‑p, PAR1 (mouse): S397‑p, PAR1 (rat): S399‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), oocyte, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  frog, monkey, rat
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  receptor shutoff (not internalization)

S399-p - PAR1 (human)
Orthologous residues
PAR1 (human): S399‑p, PAR1 (mouse): S404‑p, PAR1 (rat): S406‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), oocyte, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  frog, monkey, rat
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  receptor shutoff (not internalization)

S400-p - PAR1 (human)
Orthologous residues
PAR1 (human): S400‑p, PAR1 (mouse): T405‑p, PAR1 (rat): T407‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), oocyte, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  frog, monkey, rat
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  receptor shutoff (not internalization)

S406-p - PAR1 (human)
Orthologous residues
PAR1 (human): S406‑p, PAR1 (mouse): S411‑p, PAR1 (rat): S413‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), oocyte, Rat1 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  frog, monkey, rat
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  receptor shutoff (not internalization)


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