Curated Information
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Curated Information Page
PubMed Id: 18721752 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kaushansky A, et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol 15, 808-17 18721752
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y875-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y875‑p, HER4 iso2 (human): Y865‑p, HER4 iso3 (human): Y875‑p, HER4 iso4 (human): Y865‑p, HER4 (mouse): Y875‑p, HER4 (rat): Y875‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG2 (human) Induces micro-array binding assay

Y1035-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1035‑p, HER4 iso2 (human): Y1025‑p, HER4 iso3 (human): Y1035‑p, HER4 iso4 (human): Y1025‑p, HER4 (mouse): Y1035‑p, HER4 (rat): Y1035‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
STAT1 (human) Induces micro-array binding assay

Y1056-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1056‑p, HER4 iso2 (human): Y1046‑p, HER4 iso3 (human): ‑, HER4 iso4 (human): ‑, HER4 (mouse): Y1056‑p, HER4 (rat): Y1056‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) SH2 Induces micro-array binding assay
PIK3R2 (human) SH2 Induces micro-array binding assay
Arg (human) Induces micro-array binding assay
PIK3R3 (human) SH2 Induces micro-array binding assay
Cbl (human) Induces micro-array binding assay

Y1066-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1066‑p, HER4 iso2 (human): Y1056‑p, HER4 iso3 (human): Y1050‑p, HER4 iso4 (human): Y1040‑p, HER4 (mouse): Y1066‑p, HER4 (rat): Y1066‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1081-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1081‑p, HER4 iso2 (human): Y1071‑p, HER4 iso3 (human): Y1065‑p, HER4 iso4 (human): Y1055‑p, HER4 (mouse): Y1081‑p, HER4 (rat): Y1081‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Arg (human) Induces micro-array binding assay
Crk (human) Induces micro-array binding assay

Y1128-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1128‑p, HER4 iso2 (human): Y1118‑p, HER4 iso3 (human): Y1112‑p, HER4 iso4 (human): Y1102‑p, HER4 (mouse): Y1128‑p, HER4 (rat): Y1128‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
STAT1 (human) Induces micro-array binding assay
Src (human) SH2 Induces micro-array binding assay

Y1150-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1150‑p, HER4 iso2 (human): Y1140‑p, HER4 iso3 (human): Y1134‑p, HER4 iso4 (human): Y1124‑p, HER4 (mouse): Y1150‑p, HER4 (rat): Y1150‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Syk (human) Induces micro-array binding assay
Crk (human) Induces micro-array binding assay
Arg (human) Induces micro-array binding assay

Y1162-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1162‑p, HER4 iso2 (human): Y1152‑p, HER4 iso3 (human): Y1146‑p, HER4 iso4 (human): Y1136‑p, HER4 (mouse): Y1162‑p, HER4 (rat): Y1162‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
VAV2 (human) Induces micro-array binding assay
Arg (human) Induces micro-array binding assay

Y1188-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1188‑p, HER4 iso2 (human): Y1178‑p, HER4 iso3 (human): Y1172‑p, HER4 iso4 (human): Y1162‑p, HER4 (mouse): Y1188‑p, HER4 (rat): Y1188‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Shc1 (human) PTB Induces micro-array binding assay
Arg (human) Induces micro-array binding assay

Y1202-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1202‑p, HER4 iso2 (human): Y1192‑p, HER4 iso3 (human): Y1186‑p, HER4 iso4 (human): Y1176‑p, HER4 (mouse): Y1202‑p, HER4 (rat): Y1202‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Syk (human) Induces micro-array binding assay

Y1208-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1208‑p, HER4 iso2 (human): Y1198‑p, HER4 iso3 (human): Y1192‑p, HER4 iso4 (human): Y1182‑p, HER4 (mouse): Y1208‑p, HER4 (rat): Y1208‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1221-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1221‑p, HER4 iso2 (human): Y1211‑p, HER4 iso3 (human): Y1205‑p, HER4 iso4 (human): Y1195‑p, HER4 (mouse): Y1221‑p, HER4 (rat): Y1221‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1242-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1242‑p, HER4 iso2 (human): Y1232‑p, HER4 iso3 (human): Y1226‑p, HER4 iso4 (human): Y1216‑p, HER4 (mouse): Y1242‑p, HER4 (rat): Y1242‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Shc1 (human) PTB Induces micro-array binding assay
Arg (human) Induces micro-array binding assay

Y1258-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1258‑p, HER4 iso2 (human): Y1248‑p, HER4 iso3 (human): Y1242‑p, HER4 iso4 (human): Y1232‑p, HER4 (mouse): Y1258‑p, HER4 (rat): Y1258‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Shc1 (human) PTB Induces micro-array binding assay
Shc1 (human) PTB Induces micro-array binding assay

Y1262-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1262‑p, HER4 iso2 (human): Y1252‑p, HER4 iso3 (human): Y1246‑p, HER4 iso4 (human): Y1236‑p, HER4 (mouse): Y1262‑p, HER4 (rat): Y1262‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1266-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1266‑p, HER4 iso2 (human): Y1256‑p, HER4 iso3 (human): Y1250‑p, HER4 iso4 (human): Y1240‑p, HER4 (mouse): Y1266‑p, HER4 (rat): Y1266‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1268-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1268‑p, HER4 iso2 (human): Y1258‑p, HER4 iso3 (human): Y1252‑p, HER4 iso4 (human): Y1242‑p, HER4 (mouse): Y1268‑p, HER4 (rat): Y1268‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1284-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1284‑p, HER4 iso2 (human): Y1274‑p, HER4 iso3 (human): Y1268‑p, HER4 iso4 (human): Y1258‑p, HER4 (mouse): Y1284‑p, HER4 (rat): Y1284‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y1301-p - HER4 (human) ▲
Orthologous residues
HER4 (human): Y1301‑p, HER4 iso2 (human): Y1291‑p, HER4 iso3 (human): Y1285‑p, HER4 iso4 (human): Y1275‑p, HER4 (mouse): Y1301‑p, HER4 (rat): Y1301‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human


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