Curated Information
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Curated Information Page
PubMed Id: 18808171 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cenni V, et al. (2008) Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells. J Proteome Res 7, 4727-35 18808171
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S404-p - lamin A/C (human)
Orthologous residues
lamin A/C (human): S404‑p, lamin A/C iso2 (human): S404‑p, lamin A/C (mouse): S404‑p, lamin A/C iso3 (mouse): S292‑p, lamin A/C (rat): S404‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  Emery-Dreifuss muscular dystrophy
 Relevant cell lines - cell types - tissues:  C2C12 (myoblast), fibroblast
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Associated Diseases
Diseases: Alterations: Comments:
Emery-Dreifuss muscular dystrophy mutation of site

S404-p - lamin A/C (mouse)
Orthologous residues
lamin A/C (human): S404‑p, lamin A/C iso2 (human): S404‑p, lamin A/C (mouse): S404‑p, lamin A/C iso3 (mouse): S292‑p, lamin A/C (rat): S404‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  Emery-Dreifuss muscular dystrophy
 Relevant cell lines - cell types - tissues:  C2C12 (myoblast), fibroblast
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse

S301-p - lamin A/C (rat)
Orthologous residues
lamin A/C (human): S301‑p, lamin A/C iso2 (human): S301‑p, lamin A/C (mouse): S301‑p, lamin A/C iso3 (mouse): S189‑p, lamin A/C (rat): S301‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

S404-p - lamin A/C (rat)
Orthologous residues
lamin A/C (human): S404‑p, lamin A/C iso2 (human): S404‑p, lamin A/C (mouse): S404‑p, lamin A/C iso3 (mouse): S292‑p, lamin A/C (rat): S404‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  Emery-Dreifuss muscular dystrophy
 Relevant cell lines - cell types - tissues:  C2C12 (myoblast), fibroblast
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (mouse) phospho-antibody, phospho-motif antibody, pharmacological activator of upstream enzyme, siRNA inhibition of enzyme, modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  nucleus morphology


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