Curated Information
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Curated Information Page
PubMed Id: 18519746 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yu W, et al. (2008) CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology. J Leukoc Biol 84, 852-63 18519746
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y544-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y546‑p, CSFR (mouse): Y544‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  cell differentiation, altered, cell growth, altered

Y559-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y561‑p, CSFR (mouse): Y559‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CSF-1 increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, protein degradation
 Effect of modification (process):  cell differentiation, altered, cell growth, altered, transcription, altered

Y697-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y699‑p, CSFR (mouse): Y697‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  cell differentiation, altered

Y706-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y708‑p, CSFR (mouse): Y706‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  cytoskeletal reorganization

Y721-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y723‑p, CSFR (mouse): Y721‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  cell differentiation, altered, cytoskeletal reorganization

Y807-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y809‑p, CSFR (mouse): Y807‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  apoptosis, altered, cell differentiation, altered, cell growth, altered, transcription, altered

Y921-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y923‑p, CSFR (mouse): Y921‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse

Y974-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y969‑p, CSFR (mouse): Y974‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  cell differentiation, altered, cytoskeletal reorganization


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