Curated Information
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PubMed Id: 18519746 
Yu W, et al. (2008) CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology. J Leukoc Biol 84, 852-63 18519746
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y544-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y546‑p, CSFR (mouse): Y544‑p, CSFR (rat): Y544‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  cell differentiation, altered, cell growth, altered

Y559-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y561‑p, CSFR (mouse): Y559‑p, CSFR (rat): Y559‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
M-CSF increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, protein degradation
 Effect of modification (process):  cell differentiation, altered, cell growth, altered, transcription, altered

Y697-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y699‑p, CSFR (mouse): Y697‑p, CSFR (rat): Y697‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  cell differentiation, altered

Y706-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y708‑p, CSFR (mouse): Y706‑p, CSFR (rat): Y706‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  cytoskeletal reorganization

Y721-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y723‑p, CSFR (mouse): Y721‑p, CSFR (rat): Y721‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  cell differentiation, altered, cytoskeletal reorganization

Y807-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y809‑p, CSFR (mouse): Y807‑p, CSFR (rat): Y807‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  apoptosis, altered, cell differentiation, altered, cell growth, altered, transcription, altered

Y921-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y923‑p, CSFR (mouse): Y921‑p, CSFR (rat): Y921‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse

Y974-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y969‑p, CSFR (mouse): Y974‑p, CSFR (rat): Y974‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  macrophage-bone marrow
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (process):  cell differentiation, altered, cytoskeletal reorganization


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