Curated Information
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Curated Information Page
PubMed Id: 15193262 
Michalides R, et al. (2004) Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell 5, 597-605 15193262
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S305-p - ER-alpha (human)
Orthologous residues
ER‑alpha (human): S305‑p, ER‑alpha (mouse): S309‑p, ER‑alpha (rat): S310‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  bone cancer, breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
 Effect of modification (process):  cell growth, induced, transcription, induced
 Comments:  tamoxifen resistance
Associated Diseases
Diseases: Alterations: Comments:
breast cancer increased tamoxifen resistance


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