Curated Information
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Curated Information Page
PubMed Id: 18795890 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Schrader LA, et al. (2009) Kv4.2 is a locus for PKC and ERK/MAPK cross-talk. Biochem J 417, 705-15 18795890
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S447-p - Kv4.2 (rat)
Orthologous residues
Kv4.2 (human): S447‑p, Kv4.2 (mouse): S447‑p, Kv4.2 (rat): S447‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', COS (fibroblast), oocyte
 Cellular systems studied:  cell lines, primary cells, tissue
 Species studied:  frog, monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Downstream Regulation
 Effect of modification (function):  intracellular localization, phosphorylation
 Comments:  increases phosphorylation at T602 and T607 by ERK

S537-p - Kv4.2 (rat)
Orthologous residues
Kv4.2 (human): T537‑p, Kv4.2 (mouse): T537‑p, Kv4.2 (rat): S537‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', COS (fibroblast), oocyte
 Cellular systems studied:  cell lines, primary cells, tissue
 Species studied:  frog, monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) phospho-antibody, modification site within consensus motif, pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, phosphorylation
 Comments:  increases phosphorylation at T602 and T607 by ERK

T602-p - Kv4.2 (rat)
Orthologous residues
Kv4.2 (human): T602‑p, Kv4.2 (mouse): T602‑p, Kv4.2 (rat): T602‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
KINASE ERK2 (human)

T607-p - Kv4.2 (rat)
Orthologous residues
Kv4.2 (human): T607‑p, Kv4.2 (mouse): T607‑p, Kv4.2 (rat): T607‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
KINASE ERK2 (human)

S616-p - Kv4.2 (rat)
Orthologous residues
Kv4.2 (human): S616‑p, Kv4.2 (mouse): S616‑p, Kv4.2 (rat): S616‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK1 (human)
KINASE ERK2 (human)


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