Curated Information
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Curated Information Page
PubMed Id: 18791070 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gentile S, et al. (2008) The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity. Proc Natl Acad Sci U S A 105, 14704-8 18791070
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T895-p - Kv11.1 (human)
Orthologous residues
Kv11.1 (human): T895‑p, Kv11.1 iso2 (human): T555‑p, Kv11.1 iso5 (human): T895‑p, Kv11.1 (mouse): T897‑p, Kv11.1 (rat): T897‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Comments:  reduces basal channel current amplitude

T897-p - Kv11.1 iso5 (human)
Orthologous residues
Kv11.1 (human): K897‑p, Kv11.1 iso2 (human): K557‑p, Kv11.1 iso5 (human): T897‑p, Kv11.1 (mouse): K899‑p, Kv11.1 (rat): K899‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
 Comments:  K897T polymorphism creates phosphorylation site
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of inactive enzyme, transfection of wild-type enzyme, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Comments:  reduces basal channel current amplitude


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