Curated Information
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Curated Information Page
PubMed Id: 18445594 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Miersch S, et al. (2008) Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling. J Biol Chem 283, 18513-21 18445594
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S239-p - VASP (human)
Orthologous residues
VASP (human): S239‑p, VASP (mouse): S235‑p, VASP (rat): S236‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  Niemann-Pick disease
 Relevant cell lines - cell types - tissues:  NHF (fibroblast), NPC1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DEA-NONOate increase smaller increase in NPC1 cells (compared to NHF cells)
methyl-beta-cyclodextrin, cholesterol DEA-NONOate inhibit treatment-induced increase NHF cells
methyl-beta-cyclodextrin DEA-NONOate augment treatment-induced increase NPC1 cells


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