Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 15531580 
Shiue H, et al. (2005) Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem 280, 1688-95 15531580
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y146-p - Ezrin (human)
Orthologous residues
Ezrin (human): Y146‑p, Ezrin (mouse): Y146‑p, Ezrin (rat): Y146‑p

T567-p - Ezrin (human)
Orthologous residues
Ezrin (human): T567‑p, Ezrin (mouse): T567‑p, Ezrin (rat): T567‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt2 (human) genetic knockout/knockin of upstream enzyme, pharmacological inhibitor of upstream enzyme, antisense inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H-89 decrease
LY294002 decrease
PD169316 decrease
Downstream Regulation
 Effect of modification (function):  activity, induced


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.