Curated Information

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Curated Information Page

PubMed Id: 15531580

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Shiue H, et al. (2005) Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem 280, 1688-95 15531580

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y146-p - ezrin (human)

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Orthologous residues

ezrin (human): Y146‑p, ezrin (mouse): Y146‑p, ezrin (rat): Y146‑p

T567-p - ezrin (human)

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Orthologous residues

ezrin (human): T567‑p, ezrin (mouse): T567‑p, ezrin (rat): T567‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: Caco-2 (intestinal)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Akt2 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Akt2 (human)	genetic knockout/knockin of upstream enzyme, pharmacological inhibitor of upstream enzyme, antisense inhibition of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
H-89				decrease
LY294002				decrease
PD169316				decrease

Downstream Regulation

Effect of modification (function): activation

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