Curated Information

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Curated Information Page

PubMed Id: 11039908

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Walter AO, et al. (2000) The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 19, 4906-16 11039908

T288-p - AurA (human)

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Orthologous residues

AurA (human): T288‑p, AurA (mouse): T279‑p, AurA (rat): T281‑p, AurA (pig): T288‑p, AurA (frog): T295‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: SF9

Cellular systems studied: cell lines

Species studied: insect

Enzymes shown to modify site in vitro:

Type	Enzyme
PHOSPHATASE	PPP1CA (human)
KINASE	PKACa (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
okadaic acid				increase

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