Curated Information
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Curated Information Page
PubMed Id: 15319431 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gentile MT, et al. (2004) Mechanisms of soluble beta-amyloid impairment of endothelial function. J Biol Chem 279, 48135-42 15319431
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S117-p - eNOS (rat)
Orthologous residues
eNOS (human): P118‑p, eNOS (mouse): S117‑p, eNOS (rat): S117‑p, eNOS (rabbit): P124‑p, eNOS (pig): P120‑p, eNOS (cow): P120‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial-aorta
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid 40 increase
ACh beta-amyloid 40 no effect upon treatment-induced increase
Go 6976 beta-amyloid 40 inhibit treatment-induced increase
ACh no change compared to control
Go 6976 no change compared to control

T494-p - eNOS (rat)
Orthologous residues
eNOS (human): T495‑p, eNOS (mouse): T494‑p, eNOS (rat): T494‑p, eNOS (rabbit): T501‑p, eNOS (pig): T497‑p, eNOS (cow): T497‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial-aorta
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid 40 increase
ACh beta-amyloid 40 no effect upon treatment-induced increase
Go 6976 beta-amyloid 40 inhibit treatment-induced increase
ACh no change compared to control
Go 6976 no change compared to control

S1176-p - eNOS (rat)
Orthologous residues
eNOS (human): S1177‑p, eNOS (mouse): S1176‑p, eNOS (rat): S1176‑p, eNOS (rabbit): S1183‑p, eNOS (pig): S1179‑p, eNOS (cow): S1179‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial-aorta
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ACh increase
beta-amyloid 40 ACh inhibit treatment-induced increase
Go 6976 ACh no effect upon treatment-induced increase
beta-amyloid 40 no change compared to control
Go 6976 no change compared to control

S661-p - PKCB (rat)
Orthologous residues
PKCB (human): S661‑p, PKCB iso2 (human): S660‑p, PKCB (mouse): S628‑p, PKCB iso2 (mouse): S660‑p, PKCB (rat): S661‑p, PKCB iso2 (rat): S660‑p, PKCB (cow): S660‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  endothelial-aorta
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid 40 increase


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