Curated Information
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Curated Information Page
PubMed Id: 15210690 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Jin Z, Gao F, Flagg T, Deng X (2004) Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem 279, 40209-19 15210690
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S70-p - Bcl-2 (human) ▲
Orthologous residues
Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  NCI-H1299 (pulmonary), NCI-H69 (pulmonary), NCI-H82 (pulmonary)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
staurosporine decrease
PD98059 decrease
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited, cell growth, altered

T58-p - Myc (human) ▲
Orthologous residues
Myc (human): T58‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  NCI-H1299 (pulmonary), NCI-H69 (pulmonary), NCI-H82 (pulmonary)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
staurosporine decrease
PD98059 decrease

S62-p - Myc (human) ▲
Orthologous residues
Myc (human): S62‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  NCI-H1299 (pulmonary), NCI-H69 (pulmonary), NCI-H82 (pulmonary)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
staurosporine decrease
PD98059 decrease


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