Curated Information
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Curated Information Page
PubMed Id: 15159416 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Nagata-Ohashi K, et al. (2004) A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol 165, 465-71 15159416
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S3-p - cofilin 1 (human) ▲
Orthologous residues
cofilin 1 (human): S3‑p, cofilin 1 (mouse): S3‑p, cofilin 1 (rat): S3‑p, cofilin 1 (pig): S3‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
PHOSPHATASE SSH1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
neuregulin decrease

S937-p - SSH1 (human) ▲
Orthologous residues
SSH1 (human): S937‑p, SSH1 iso2 (human): ‑, SSH1 iso4 (human): S625‑p, SSH1 (mouse): S929‑p, SSH1 (rat): S891‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Downstream Regulation
 Effect of modification (function):  inhibition, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces in vitro

S978-p - SSH1 (human) ▲
Orthologous residues
SSH1 (human): S978‑p, SSH1 iso2 (human): ‑, SSH1 iso4 (human): S666‑p, SSH1 (mouse): S970‑p, SSH1 (rat): S932‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), COS (fibroblast), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
neuregulin decrease
Downstream Regulation
 Effect of modification (function):  inhibition, intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces in vitro


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