Curated Information
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Curated Information Page
PubMed Id: 14992595 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fielding PE, et al. (2004) Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80. Biochemistry 43, 2578-86 14992595
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y14-p - Caveolin-1 (human)
Orthologous residues
Caveolin‑1 (human): Y14‑p, Caveolin‑1 (mouse): Y14‑p, Caveolin‑1 (rat): Y14‑p, Caveolin‑1 (dog): Y14‑p, Caveolin‑1 (sheep): Y14‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  vascular smooth muscle cell ('muscle, smooth')
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
AG1296 PDGF inhibit treatment-induced increase
PP2 PDGF inhibit treatment-induced increase
SU6656 PDGF inhibit treatment-induced increase

S80-p - Caveolin-1 (human)
Orthologous residues
Caveolin‑1 (human): S80‑p, Caveolin‑1 (mouse): S80‑p, Caveolin‑1 (rat): S80‑p, Caveolin‑1 (dog): S80‑p, Caveolin‑1 (sheep): S80‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  vascular smooth muscle cell ('muscle, smooth')
 Cellular systems studied:  cell lines
 Species studied:  human


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