Curated Information

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Curated Information Page

PubMed Id: 11313479

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001) Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Mol Cell Biol 21, 3534-46 11313479

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S197-p - FOXO4 (human)

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Orthologous residues

FOXO4 (human): S197‑p, FOXO4 (mouse): S197‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 293 (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], BHK-21 (fibroblast), HeLa (cervical)

Cellular systems studied: cell lines

Species studied: hamster, human, mouse

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Akt1 (human)	pharmacological activator of upstream enzyme, phospho-antibody

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
insulin				increase
leptomycin B	insulin			no effect upon treatment-induced increase

Downstream Regulation

Effect of modification (function): intracellular localization

Effect of modification (process): transcription, altered

S262-p - FOXO4 (human)

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