Curated Information
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Curated Information Page
PubMed Id: 15345593 
Kindler T, et al. (2005) Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). Blood 105, 335-40 15345593
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y591-p - FLT3 (human)
Orthologous residues
FLT3 (human): Y591‑p, FLT3 (mouse): Y592‑p
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  32D (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PKC412 decrease
FL increase
PKC412 FL inhibit treatment-induced increase

Y842-p - FLT3 (human)
Orthologous residues
FLT3 (human): Y842‑p, FLT3 (mouse): Y845‑p
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia, acute myelogenous leukemia
 Relevant cell lines - cell types - tissues:  32D (myeloid), myeloblast
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  phosphorylation, protein conformation
 Effect of modification (process):  apoptosis, inhibited, cell growth, altered
 Comments:  FLT3 Y842C -transfected cells show constitutive FLT3 tyrosine phosphorylation and activation
Associated Diseases
Diseases: Alterations: Comments:
acute myelogenous leukemia mutation of site

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