Curated Information
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Curated Information Page
PubMed Id: 15642359 
Hekman M, et al. (2005) Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation. FEBS Lett 579, 464-8 15642359
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S259-p - RAF1 (human)
Orthologous residues
RAF1 (human): S259‑p, RAF1 (mouse): S259‑p, RAF1 (rat): S259‑p, RAF1 (chicken): S259‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  SF9
 Cellular systems studied:  cell lines
 Species studied:  insect

S296-p - RAF1 (human)
Orthologous residues
RAF1 (human): S296‑p, RAF1 (mouse): S296‑p, RAF1 (rat): S296‑p, RAF1 (chicken): S296‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), SF9
 Cellular systems studied:  cell lines
 Species studied:  insect, monkey
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

S301-p - RAF1 (human)
Orthologous residues
RAF1 (human): S301‑p, RAF1 (mouse): S301‑p, RAF1 (rat): S301‑p, RAF1 (chicken): S301‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), SF9
 Cellular systems studied:  cell lines
 Species studied:  insect, monkey
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

S621-p - RAF1 (human)
Orthologous residues
RAF1 (human): S621‑p, RAF1 (mouse): S621‑p, RAF1 (rat): S621‑p, RAF1 (chicken): S621‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  SF9
 Cellular systems studied:  cell lines
 Species studied:  insect


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