Curated Information
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Curated Information Page
PubMed Id: 15661742 
Kim SA, Yoon JH, Lee SH, Ahn SG (2005) Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress. J Biol Chem 280, 12653-7 15661742
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S415-p - HSF1 (mouse)
Orthologous residues
HSF1 (human): S419‑p, HSF1 (mouse): S415‑p, HSF1 iso2 (mouse): , HSF1 (rat): S415‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (mouse) transfection of wild-type enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat shock increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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