Curated Information

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PubMed Id: 15661742

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Kim SA, Yoon JH, Lee SH, Ahn SG (2005) Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress. J Biol Chem 280, 12653-7 15661742

S415-p - HSF1 (mouse)

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Orthologous residues

HSF1 (human): S419‑p, HSF1 (mouse): S415‑p, HSF1 iso2 (mouse): ‑, HSF1 (rat): S415‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PLK1 (mouse)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PLK1 (mouse)	transfection of wild-type enzyme, co-immunoprecipitation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
heat shock				increase

Downstream Regulation

Effect of modification (function): intracellular localization

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