Curated Information
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PubMed Id: 18406327 
Bhaskara S, et al. (2008) Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30, 61-72 18406327
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S140-p - H2AX (mouse)
Orthologous residues
H2AX (human): S140‑p, H2AX (mouse): S140‑p, H2AX (rat): S140‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) increase null in MEF cells
siRNA HDAC2 (mouse) increase
ionizing radiation increase
ionizing radiation HDAC3 (mouse) augment treatment-induced increase null in MEF cells

K10-ac - H3 (mouse)
Orthologous residues
H3 (human): K10‑ac, H3 (mouse): K10‑ac, H3 iso2 (mouse): K10‑ac, H3 iso3 (mouse): K10‑ac, H3 (rat): K10‑ac, H3 iso3 (rat): K10‑ac, H3 (pig): K10‑ac, H3 (chicken): K10‑ac, H3 (cow): K10‑ac
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) increase null in MEF cells

K10-m3 - H3 (mouse)
Orthologous residues
H3 (human): K10‑m3, H3 (mouse): K10‑m3, H3 iso2 (mouse): K10‑m3, H3 iso3 (mouse): K10‑m3, H3 (rat): K10‑m3, H3 iso3 (rat): K10‑m3, H3 (pig): K10‑m3, H3 (chicken): K10‑m3, H3 (cow): K10‑m3
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) decrease null in MEF cells

S11-p - H3 (mouse)
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) no change compared to control null in MEF cells
HDAC3 (mouse) decrease null in 3T3 cells
caffeine HDAC3 (mouse) inhibit treatment-induced decrease

K15-ac - H3 (mouse)
Orthologous residues
H3 (human): K15‑ac, H3 (mouse): K15‑ac, H3 iso2 (mouse): K15‑ac, H3 iso3 (mouse): K15‑ac, H3 (rat): K15‑ac, H3 iso3 (rat): K15‑ac, H3 (pig): K15‑ac, H3 (chicken): K15‑ac, H3 (cow): K15‑ac
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) increase null in MEF cells

S108-p - MCM2 (mouse)
Orthologous residues
MCM2 (human): S108‑p, MCM2 iso4 (human): S108‑p, MCM2 (mouse): S108‑p, MCM2 (rat): S109‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) increase null in MEF cells

S824-p - TIF1B (mouse)
Orthologous residues
TIF1B (human): S824‑p, TIF1B (mouse): S824‑p, TIF1B (rat): S825‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HDAC3 (mouse) increase null in MEF cells
siRNA HDAC1 (mouse) increase
siRNA HDAC2 (mouse) increase
ionizing radiation increase
ionizing radiation HDAC3 (mouse) augment treatment-induced increase null in MEF cells


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