Curated Information

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Curated Information Page

PubMed Id: 18406329

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Heo K, et al. (2008) FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell 30, 86-97 18406329

S140-p - H2AX (human)

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Orthologous residues

H2AX (human): S140‑p, H2AX (mouse): S140‑p, H2AX (rat): S140‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 293T (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	DNA-PK (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
etoposide				increase

Downstream Regulation

Effect of modification (process): cytoskeletal reorganization

Comments: destabilizes nucleosome structure

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