Curated Information
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Curated Information Page
PubMed Id: 18562279 
Okada M, Jang SW, Ye K (2008) Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. Proc Natl Acad Sci U S A 105, 8649-54 18562279
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S34-p - THOC4 (human)
Orthologous residues
THOC4 (human): S34‑p, THOC4 (mouse): S34‑p, THOC4 (rat): S34‑p
Characterization
 Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

T219-p - THOC4 (human)
Orthologous residues
THOC4 (human): T219‑p, THOC4 (mouse): T217‑p, THOC4 (rat): T218‑p
Characterization
 Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) modification site within consensus motif, siRNA inhibition of enzyme, genetic transfer of dominant-negative enzyme, phospho-antibody, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  activity, induced
 Effect of modification (process):  cell growth, altered
 Comments:  required for THOC4 mRNA export activity


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