Curated Information
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PubMed Id: 18587398 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Butler B, Kastendieck DH, Cooper JA (2008) Differently phosphorylated forms of the cortactin homolog HS1 mediate distinct functions in natural killer cells. Nat Immunol 9, 887-97 18587398
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y378-p - HS1 (human) ▲
Orthologous residues
HS1 (human): Y378‑p, HS1 (mouse): Y388‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (process):  cell motility, altered

Y397-p - HS1 (human) ▲
Orthologous residues
HS1 (human): Y397‑p, HS1 (mouse): Y405‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered, cytoskeletal reorganization

Y397-p - Lyn (human) ▲
Orthologous residues
Lyn (human): Y397‑p, Lyn iso2 (human): Y376‑p, Lyn (mouse): Y397‑p, Lyn iso2 (mouse): Y376‑p, Lyn (rat): Y397‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin, phorbol ester HS1 (human) increase
siRNA fibronectin, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA
ICAM-1, phorbol ester HS1 (human) increase
siRNA ICAM-1, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA

Y467-p - PIK3R1 (human) ▲
Orthologous residues
PIK3R1 (human): Y467‑p, PIK3R1 (mouse): Y467‑p, PIK3R1 (rat): Y467‑p, PIK3R1 (cow): Y467‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin, phorbol ester HS1 (human) increase
siRNA fibronectin, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA
ICAM-1, phorbol ester HS1 (human) increase
siRNA ICAM-1, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA

Y402-p - Pyk2 (human) ▲
Orthologous residues
Pyk2 (human): Y402‑p, Pyk2 iso2 (human): Y402‑p, Pyk2 (mouse): Y402‑p, Pyk2 (rat): Y402‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin, phorbol ester HS1 (human) increase
siRNA fibronectin, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA
ICAM-1, phorbol ester HS1 (human) increase
siRNA ICAM-1, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA

Y174-p - VAV1 (human) ▲
Orthologous residues
VAV1 (human): Y174‑p, VAV1 (mouse): Y174‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  natural killer cell-blood
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin, phorbol ester HS1 (human) increase
siRNA fibronectin, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA
ICAM-1, phorbol ester HS1 (human) increase
siRNA ICAM-1, phorbol ester HS1 (human) inhibit treatment-induced increase HS1 siRNA


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