Curated Information
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Curated Information Page
PubMed Id: 15545601 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Aiba Y, et al. (2004) Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A 101, 16612-7 15545601
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T133-p - RasGRP3 (chicken) ▲
Orthologous residues
RasGRP3 (human): T133‑p, RasGRP3 (mouse): T133‑p, RasGRP3 (rat): T133‑p, RasGRP3 (chicken): T133‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) transfection of wild-type enzyme, mutation in upstream enzyme recognition motif, genetic knockout/knockin of upstream enzyme, co-immunoprecipitation, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  activation


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