Curated Information
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Curated Information Page
PubMed Id: 15545601 
Aiba Y, et al. (2004) Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A 101, 16612-7 15545601
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T133-p - RASGRP3 (chicken)
Orthologous residues
RASGRP3 (human): T133‑p, RASGRP3 iso2 (human): T133‑p, RASGRP3 (mouse): T133‑p, RASGRP3 (rat): T133‑p, RASGRP3 (chicken): T133‑p
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) mutation in upstream enzyme recognition motif, pharmacological inhibitor of upstream enzyme, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme, co-immunoprecipitation
Downstream Regulation
 Effect of modification (function):  activity, induced

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