Curated Information
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Curated Information Page
PubMed Id: 15539407 
Zhang P, et al. (2005) Regulated association of protein kinase B/Akt with breast tumor kinase. J Biol Chem 280, 1982-91 15539407
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y447-p - Brk (human)
Orthologous residues
Brk (human): Y447‑p, Brk (mouse): Y447‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), HaCaT (keratinocyte), T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Akt1 (human) Disrupts activity, inhibited co-immunoprecipitation


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