Curated Information
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Curated Information Page
PubMed Id: 15550393 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kaur R, et al. (2005) Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. J Biol Chem 280, 3323-30 15550393
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S602-p - PAK5 (human)
Orthologous residues
PAK5 (human): S602‑p, PAK5 (mouse): S602‑p, PAK5 (rat): S601‑p

S165-p - PAK6 (human)
Orthologous residues
PAK6 (human): S165‑p, PAK6 (mouse): S165‑p, PAK6 (rat): S165‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE P38A (human) pharmacological inhibitor of upstream enzyme, transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SB203580 decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S560-p - PAK6 (human)
Orthologous residues
PAK6 (human): S560‑p, PAK6 (mouse): S561‑p, PAK6 (rat): S560‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y566-p - PAK6 (human)
Orthologous residues
PAK6 (human): Y566‑p, PAK6 (mouse): Y567‑p, PAK6 (rat): Y566‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MKK6 (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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